Choline phospholipid metabolism in human ovarian tumor progression: a MRS study
نویسندگان
چکیده
INTRODUCTION Epithelial ovarian cancer (EOC) is the gynecologic neoplasia with the highest death rate, partly because of limited understanding of its patho-physiology mechanisms. Early diagnosis of EOC is critically important in disease prognosis and patient survival. Non-invasive detection of response to treatment and relapse are crucial to improve patient management. Detection by MRS of abnormal levels of choline (Cho) phospholipid metabolites has recently allowed identification of novel fingerprints of tumor progression in breast, prostate and colon carcinomas and in brain tumors (1, 2). Our project is therefore aimed at evaluating the potential of monitoring by MRS abnormal Cho-phospholipid metabolism in ovary cancer.
منابع مشابه
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